Cladosporium
One
of the most commonly isolated from indoor and outdoor air,
Cladosporium spp. are found on decaying plants, woody plants,
food, straw, soil, paint, textiles, and the surface of fiberglass
duct liner in the interior of supply ducts. This
genus of mold are pigmented dark green to black in the front,
black on the reverse with a velvety to powdery texture.
There
are over 30 species in the Cladosporium genus. The most common are
C. elatum, C. herbarum, C. sphaerospermum, and C.
cladosporioides. These fungi are the causative
agents of skin lesions, keratitis, nail fungus, sinusitis, asthma,
and pulmonary
infections. Acute symptoms of exposure to
Cladosporium are edema and bronchiospasms, and chronic exposure may
lead to
pulmonary emphysema.
Fusarium
A
common soil fungus and inhabitant on a wide array of plants, this fungi is often
found
in humidifiers and has been isolated from water-damaged carpets and
a variety of other building materials. Human exposure may occur through
ingestion of contaminated grains and possibly through the inhalation of
spores. Fusarium spp. are frequently involved with eye, skin, and nail
infections. More severely it can produce hemorrhagic syndrome (alimentary
toxic aleukia) in humans which is characterized by nausea, vomiting, diarrhea,
dermatitis, and extensive internal bleeding.
Several species can produce the trichothecene toxins which
target the circulatory, alimentary, skin, and nervous systems.
Vomitoxin is one such tricothecene mycotoxin that has been
associated with outbreaks of acute gastrointestinal illness
in humans. Zearalenone is another mycotoxin produced by Fusarium.
It is similar in structure to the female sex hormone estrogen
and targets the reproductive organs.
Mycotoxins
During the digestion of substrates, fungi secrete enzymes into
nutrients in order to break down complex compounds into simpler
compounds that can be taken up by the fungi and used as nutrition.
These digested nutrients produce secondary metabolic byproducts
called mycotoxins that are released to give the fungi a competitive
edge over other microorganisms and fungi. Unfortunately, mycotoxins
can also be incredibly toxic to humans causing a variety of responses
including cold/flu-like symptoms, sore throats, headaches, nose
bleeds, fatigue, diarrhea, dermatitis, and immune suppression.
Some mycotoxins may also be carcinogenic and teratogenic. Molds
that have been known to potentially produce these toxins are
Acremonium, Alternaria, Aspergillus, Chaetomium, Cladosporium,
Fusarium, Penicillium, and Stachybotrys.
Even
though these molds may potentially produce mycotoxins, they
will not do so unless specific environmental conditions
exist. Currently, it is unknown exactly what conditions promote
the growth of mycotoxin production and more scientific research
needs to be conducted on this topic for it to be fully understood.
CLICK
HERE for Extensive
Mycotoxin List
TYPES OF MYCOTOXINS
Aflatoxin:
This mycotoxin is primarily
produced by Aspergillus species. It is one of the most potent
carcinogens known to
man and has been linked
to a wide array of human health problems. The FDA has established
a maximum allowable
level of total
aflatoxin in food commodities
of 20 parts per billion (ppb) and the maximum level for aflatoxin
in milk products is
0.5 ppb.
Ochratoxin: This mycotoxin is primarily produced by species of
Penicillium and Aspergillus. It can be damaging
to the kidneys
/ liver, and it is a suspected carcinogen. There
is also evidence supporting it’s role in
impairing immune system function.
Tricothecene: This mycotoxin is produced
by Stachybotrys spp. and Fusarium spp and has even been indicated
as a potential agent
for use as a biological weapon.
One of the more deadly mycotoxins, if it is ingested in large amounts
it can severely damage the
entire digestive tract and
cause rapid death due to internal hemorrhaging. It has also been
implicated in human disease
such as infant pulmonary hemosiderosis.
In 1986, Croft et al., with funding from the Army, reported chronic
inhalation due
to mycotoxicosis from tricothecene
exposure in a household in Chicago. For information on this subject
go to: http://gcrc.meds.cwru.edu/stachy/
Penicillium
These fungi are commonly found in soil, food, cellulose, grains,
paint, carpet, wallpaper, interior fiberglass duct insulation,
and decaying vegetation. Penicillium may cause hypersensitivity
pneumonitis, asthma, and allergic alveolitis in susceptible individuals.
The genus Penicillium has several species. The most common
ones include Penicillium chrysogenum, Penicillium citrinum,
Penicillium janthinellum, Penicillium marneffei, and Penicillium
purpurogenum.
This fungi has been isolated from patients with keratitis,
ear infections, pneumonia, endocarditis, peritonitis, and urinary
tract infections. Penicillium infections are most commonly
exhibited in immunosuppressed individuals. For example, P.
marneffei is a fungus abundant in Southeast Asia that typically
infects patients with AIDS in this area. Infection with P.marneffei
is acquired via inhalation and initially results in a pulmonary
infection and then spreads to other areas of the body (lymphatic
system, liver, spleen, and bones), and is often fatal. An indication
of infection is the appearance of papules that resemble acne
on the face, trunk, and extremities.
Penicillim spp. do have the ability to produce mycotoxins.
The mycotoxin known as Ochratoxin A, which is nephrotoxic and
carcinogenic, may be produced by Penicillium verrucosum. Verrucosidin
is another mycotoxin produced by this fungus that exhibits
neurotoxity. Penicillic acid is another mycotoxin that is nephrotoxic
(causes kidney and liver damage).
Stachybotrys
chartarum (atra)
This group of molds can thrive on water damaged, cellulose-rich
material in buildings such as sheet rock, paper,
ceiling tiles, insulation backing, wallpaper, etc. In the
majority
of cases where Stachybotrys is found indoors, water damage
has gone unnoticed or ignored since it requires extended
periods of time with increased levels of moisture for growth
to occur. Stachybotrys is usually black and slimy in appearance.
Events of water intrusion that are addressed quickly tends
to support the growth of more xerophilic fungi such as Pencillium
and Aspergillus.
Stachybotrys is another fungi that has the ability to produce
mycotoxins, ones that are extremely toxic, suspected carcinogens,
and immunosuppressive. Exposure to these mycotoxins can result
through inhalation, ingestion, and dermal exposure. Symptoms
of exposure include dermatitis, cough, rhinitis, nose bleeds,
cold and flu-like symptoms, headache, general malaise, and
fever.
CLICK
HERE for pictures of Stachybotrys (Some Are Extreme Cases)